Can Recarbrio Be a Panacea for Complicated Urinal Tract Infection?

R&D of Merck & Co wins in the battle between humans and ingenious bacteria, at least for now.

Development of new antibacterial drugs is a challenge of the early 21st century. Although the range of antibiotics is increasing year after year, the race for better treatment options can be never finished, as bacteria become resistant and, after some time, traditional preparations are no longer effective. That is why the FDA supports the clinical development of drugs for infections of different genesis, including Complicated Urinal Tract Infections (cUTIs).

Recarbrio

In July 2019, the FDA approved Merck’s Recarbrio® for treatment of cUTIs in patients who have resistance to traditional medication plans. It will be available for sale in late 2019. But receiving QIDP designation does not necessarily mean that medication will be successful commercially and therapeutically.

Complicated UTIs versus Simple UTIs

Urinary Tract Infections are more common in women. The obvious example of simple UTI is cystitis of different genesis. UTIs are caused by Gram-negative bacteria that get to urinary tract or kidney. Simple infections can be treated with a short course of anti-bacterial drugs, such as nitrofurantoin (marketed as Macrobid and Furadantin), sulfamethoxazole-trimethoprim (Bactrim DS), fosfomycin (Monurol), cephalosporin of the third generation, and others.

The definition of complicated UTIs is quite vague. Any urinary infections that are chronic and resistant to the therapy can be considered complicated.

UTIs also include:

  • Pyelonephritis (kidney inflammation).
  • Complications associated with diabetes.
  • Complications associated with pregnancy.
  • Functional changes of the urinary tract.
  • Sepsis.

Urinary infections in men are less common but always complicated due to the different structure of the urinary tract. Complicated UTIs are subject to long-term (up to 6 months) treatment with antibiotics and complex antibacterial drugs.

Treatment Options for cUTIs

For outpatients, complex treatment is assigned, including:

  • One time IV injection of aminoglycoside, ceftriaxone, or fluoroquinolone.
  • Oral antibiotics (5–7 days), such as fluoroquinolones (levofloxacin or ciprofloxacin).
  • Trimethoprim/sulfamethoxazole for 14 days.

Although effective, quinolones have many serious side effects and recommended by the FDA only in cases when other options are failed.

For acute infections treated in hospital, injectable versions of quinolones are used that still affect tendons and muscles, as well as the nervous system, but have fewer side effects involving the digestive tract. The course for acute pyelonephritis may include:

  • IV fluoroquinolone
  • Extended-spectrum penicillin
  • Aminoglycoside
  • Ceftolozane/tazobactam (3rd generation cephalosporin)

Why Recarbrio is Special?

The goal of the developers was to find effective medicine to treat resistant bacteria with fewer complications. Recarbrio is a combination injectable drug for IV injections including three components:

  • Imipenem (a penem antibiotic).
  • Ilastatin (an inhibitor of renal enzyme dehydropeptidase).
  • Relebactam (a betalactamase inhibitor).

FDA approved Recarbrio for serious life treating infections when other treatments were ineffective. The challenge of Recarbrio combo was in adding relabactam to supplement imipenem and ilastatin that were already used together in Primaxin. It is expected that a new ingredient can enhance the effectiveness of an antibiotic to combat bacteria that have already developed resistance to a wide spectrum of antibiotics.

The competitiveness of Recarbrio comparing to previously used antibacterial agents remains questionable, though promising. In two clinical trials, it showed high effectiveness and, probably, fewer side effects than fluoroquinolones, but common side effects still include headache, vomiting, diarrhea, nausea, pyrexia, phlebitis/infusion site reactions, and hypertension.

Pharmaceutical companies are not very enthusiastic about developing new antibacterial drugs, as they are difficult to market. Previously, Merck & Co already had struggle while promoting Zerbaxa (ceftolozane/tazobactam), but it was improved after FDA additionally approved Zerbaxa for some pulmonary diseases.

The management of Merck & Co refrains from commenting on their commercial perspectives with Recarbrio. Recarbrio has also been approved for intra-abdominal infections, which gives it wide perspectives, but it is not time yet to conclude whether the medication can be a panacea for those patients who before had limited or no treatment options for complicated urinary tract infections.

Cheap Drugs at My Canadian Pharmacy – Effective Method to Pay Less

Spend less on your pills!

Our team knows how to make your family and you feel healthy, wealthy, and strong. These trained pharmacists and numerous medical specialists will help you purchase your regular prescription and non-prescription medication courses and pills for your general healthcare issues cheaper and faster.

  • There’s no need to stay in lines;
  • You don’t have to discuss your sexual health issues with a pharmacist eye-to-eye;
  • Your expenses will be significantly lower in comparison to your regular shopping for meds.

Pay Less with No Hustle

How does it happen that a typical online pharmacy offers brand and officially certified medications this cheap?

Magical Generics

These are effective replacements of the original drug courses. They have the same ingredients in the structure and they only differ in additional components. Generics usually don’t look the same as the originals. They have non-habitual shapes and their overall design has nothing in common with the brands. These pills are often released in a wider range of dosage options.

Lower Cost Production

The cheapness is never connected with low-standard technologies or illegal components in the base. The principle explanation is the absence of the necessity to invest in advertising. Generics don’t need any kind of promotion, because the interested customers search for them on their own. The experienced physicians, as well as pharmacists in the regular drugstores, are always ready to help you make the wise choice that will save your expenses on curing and rehab measures.

Brands & Safe Copies

There’s nothing wrong in a desire to purchase branded medications from the renowned manufacturers. Nevertheless, you have to understand that copies released in Canada and in the United States are produced in accordance with the state laws. None of the representatives of the pharmaceutical business wants to risk your health and have their reputation hurt.

Extensive Range of Products

Unfortunately, not all meds have their generic copies. This is caused by the restrictions officially announced by the manufacturers of the brands. It’s natural that they don’t want the other pharmaceutical companies to outperform their success. There are certain meds that you’ll never get cheaper than it is possible. However, there’s always a way to pay less for the following groups of medical supplies:

  • Cardiovascular and blood pressure pills;
  • Cholesterol and diabetes effective treatments;
  • Cancer meds;
  • Antibiotics and numerous anti-viral treatment courses;
  • General healthcare drugs, including products for your beautiful exterior as well.

Pay Less for Robust Sexual Health

My Canadian Pharmacy mostly focus on men’s and women’s intimate health issues. They know that it’s always hard to accept your weakness and openly talk about it. It’s especially crucial for men. Premature Ejaculation (PE), as well as Erectile Dysfunction, (ED), can develop at any age. They can also be consequences of other health conditions.

Free Discreet Consultations

Hold on to the thought that a medical specialist from a renowned and a highly reputable drugstore will be able to give you advice on what medical specialist you need to consult if you suffer from PE, ED, or other sexual malfunctions. Your trouble might have underlying causes, including weakness of your heart muscles or chronic blood pressure conditions. The pharmaceutical specialists will provide you with free consultations on the phone or via the chat and share sufficient advice on what medical specialist to turn to. If you deal with the underlying cause, you’ll quickly get rid of the potential complications.

Convenient Drug Supply Programs

One of the most beneficial things about dealing with online pharmacies is a possibility to fully control the number of meds you take as well as the consistency of the treatment course. Telemedicine is one of the greatest tools to the improvement of your well-being while saving your time and money.

This pharmacy is one of the most powerful in the market with warehouses situated all over the country and over the border. Hundreds of staff members will try hard to help you stay in line with your current therapy.

Enjoy the following features for your membership:

  • Notifications about promotions and seasonal discounts on your favorite pills;
  • Regular price reductions for bulk orders;
  • Free pills to try as bonuses with every package.

As soon as you get your regular prescription from your physician (My Canadian Pharmacy urges the customers to consult their physicians first before they proceed with the order), get in contact with one of the online staff members for more information on how you can save on your treatment.

Cheap Drugs Are Closer Than Ever

  • Consult your physician;
  • Get a relevant prescription;
  • Sign in;
  • Pick out the needed medications and share your prescription information (this is highly important for your safety);
  • Get real bargains while buying high-end replacements of your prescription meds;
  • Enjoy the impeccable customer support.

Better health elevates your mood!

Over-The-Counter (OTC) Drugs: Facts and Popular Categories in Canada and US

Over-the-counter medications, also known as OTC, is a group of drugs sold without a prescription. Prescription medications, on the other hand, can be sold only to those holding a prescription from a licensed physician. This classification is necessary to prevent drug misuse and protect the consumer — and other people — from its negative consequences.

How and why drugs are classified into Prescription and Over-The-Counter (OTC)?

otc-drugs

Prescription and over-the-counter drug lists are managed by national health agencies such as the FDA in the United States and Health Canada in Canada. The drug is included in the non-prescription list when experts consider it safe and effective enough for self-administration. As such, non-prescription drugs should not be addictive or have a toxic effect. The patient should be able to self-diagnose the condition in which the drug is indicated, and conduct treatment based on the information provided in the leaflet.

However, evaluating each product isn’t necessary, as the decision is made for the generic drug, and not for the whole drug composition. For instance, a number of cold and cough medicines have dextromethorphan as their active agent, which makes these products over-the-counter.

Interesting facts about over-the-counter drugs

  1. Medicines can switch from one list to another. When a drug proves to be safe over time, it can be transferred to the OTC category. This is a standard procedure, as in case with levonorgestrel, the emergency contraceptive drug known as “the morning-after pill”, which is now freely available in Canada and the US. Discovering new facts about a drug, such as previously unknown dangerous side effects, etc., can also lead to an opposite switch from OTC to Rx, although it’s very uncommon.
  2. Formerly, drugs were mostly sold without a prescription. Before the relevant agencies appeared, it was possible to sell almost any substance claiming any properties or benefits. Some over-the-counter drugs contained alcohol, cocaine, marijuana, and opium, without any warning on the label.
  3. Although the respective lists in Canada and the US are quite similar, they are not identical. In Canada, drugs like Polysporin, Codeine, Pseudoephedrine (nasal decongestant), Robaxacet (analgesic and a muscle relaxant for back pain), Voltaren (NSAID, topical pain ointment), and many others can be purchased without a prescription, which is not the case in the US.
  4. OTC drugs prices in the US and Canada can vary significantly. As stated by a medical online-journal, many Americans travel to Canada to buy insulin, with prices growing rapidly in both countries. In Canada, a three-month supply of insulin pens can be obtained for $500, while in the USA the same product will cost $1,150.
  5. Over-the-counter drugs are considered safe for self-administration, however, they still require caution and responsible use. Exceeding the recommended dose may cause serious side effects, as in the case of dextromethorphan. DXM is known to be widely misused by the youth in order to “get high”. However, DMX abuse can lead to a heart attack, liver and kidney damage, depression and other mental disorders. Moreover, the FDA has reported 13 deaths related to common laxatives, as the latter can cause serious dehydration in case of long-term usage.

Most popular Over-The-Counter drug categories

OTC drugs are most commonly used to treat mild pains and aches, cough and common cold, fever, upset stomach, vomit, nausea, and heartburn. Less common uses include eye care, feminine hygiene, anti-fungal, etc. Here is an overview of the most popular OTC drugs sold in the US and Canada.

  1. Cold and cough medicines

Cold and cough drugs have several sub-categories for alleviating different symptoms of cold and flu. Many products contain two, three or more active agents to address several symptoms at a time.

Available as: nasal sprays and drops, oral medications

Decongestants: for congested nose; prevent liquid leakage by narrowing the blood vessels in the nasal area.

Popular products: pseudoephedrine (Sudafed, Advil, etc.)

Antihistamines: alleviate allergic reactions such as runny nose, sneezing and itching.

Popular products: brompheniramine (marketed as Brovex, Veltane, Tanacof-XR, VaZol);

chlorpheniramine (Advil Allergy, NeoCitran, Novo-Pheniram).

Expectorants: thin mucus making it easier to cough up.

Popular products: guaifenesin (Hycofenix, Mucinex, Benylin, Buckley’s).

Cough suppressants: dextromethorphan (Delsym, Balminil, NeoCitran, Mucinex DM).

  1. Antacids: for hearth burn, acid reflux and indigestion.

Working action: antacids help to neutralize stomach acid.

Available as: liquids, chewables, tablets to dissolve in water.

Popular products: calcium carbonate (Alka-Seltzer Heartburn), magnesium hydroxide (Mylanta).

  1. Pain relief: to treat mild and moderate pain.

Available as: tablets, caplets, gelcaps, and liquids.

Popular products: acetaminophen, also known as paracetamol (Tylenol, Panadol);

NSAIDs (nonsteroidal anti-inflammatory drugs): ibuprofen, naproxen, meloxicam.

  1. Laxatives: relieving constipation by increasing stool motility.

Available as: pills, capsules, liquids, suppositories.

Warning: prolonged use of laxatives can cause serious dehydration, kidney injury, and other complications. It is recommended to try fiber-rich diet, exercise and other natural means to prevent constipation.

Popular products: bulk-forming laxatives, fiber (Citrucel, Hydrocil, Psyllium), stool softeners (Colace, Dulcolax), stimulant laxatives (Alophen, Senosol, Clenpiq), osmotic laxatives (Fleet glycerin suppositories), Constulose, Glycolax.

  1. Sleeping aids

Most OTC sleeping aids contain antihistamines because of their sedative effects. Unfortunately, our body quickly develops tolerance, so they are not suitable for long-term use.

OTC solutions for insomnia may include diphenhydramine, doxylamine succinate, melatonin, valerian.

Viagra and Heartburn: What Should You Know about It?

HeartburnHeartburn is the feeling of burning behind the sternum, which spreads along the esophagus. It can be accompanied by a feeling of fullness of the stomach, bitterness or acid in the mouth, and get strengthened with tilts and lying down. Heartburn occurs when pelting, or reflux, the contents of the stomach into the esophagus. Aggressive gastric juice irritates the walls of the esophagus, which is manifested by burning.

Most often, heartburn occurs in people predisposed to it due to improper diet – eating dry food, on the go, abuse of coffee, strong tea, and drinks with mint. Often the burning sensation behind the sternum arises from the increase in intra-abdominal pressure during excess weight, pregnancy, because of a tightly tight belt or when lifting weights. Also, heartburn can occur after the intake of Viagra. Find out how to avoid heartburn with Viagra.

Causes of Heartburn

The immediate cause of heartburn, as it was already mentioned, is the weakening of the esophageal sphincter, leading to reflux. Also, the increased content of hydrochloric acid in gastric juice matters. These processes, in turn, are observed in many diseases and physiological states.

Diseases of the gastrointestinal tract:

  • Gastroesophageal reflux disease (abbreviated GERD), associated with insufficiency of the esophageal sphincter. Heartburn occurs usually immediately or 20–30 minutes after eating, often accompanied by a belching.
  • Gastritis with high acidity. The patient feels heartburn 15–30 minutes after eating. Almost always this is accompanied by complaints of pain in the epigastric region.
  • A peptic ulcer. Burning behind the breastbone occurs 15–30 minutes after eating in case of stomach damage and 1.5–2 hours after the process is localized in the duodenum.
  • Cholecystitis and cholelithiasis

Other causes of heartburn include:

  • Dysfunction of diet. Irregular eating, overeating, and eating in a hurry contribute to the weakening of the esophageal sphincter and provokes heartburn.
  • Errors in the diet. Fatty, fried, spicy dishes, fresh pastries, tea, coffee, chocolate – the abuse of such food can cause heartburn even in healthy people.
  • Taking certain medications, in particular NSAIDs, hypotensive drugs can also cause heartburn.
  • Taking Viagra. Heartburn because of Viagra is common since this is one of the side effects of the drug.
  • Unhealthy lifestyle – bad habits (smoking, alcohol abuse), and chronic stress.
  • Pregnancy is one of the possible causes of heartburn in women. Reflux occurs due to increased intra-abdominal pressure. The same mechanism of heartburn is observed with excess weight.
  • Some external factors – tight clothing, lifting weights, and other such circumstances sometimes provoke heartburn in healthy people.

Heartburn with Viagra

Viagra is one of the most popular drugs that help treat ED. It was a real salvation for many men who have certain problems with erection. It is well-known that Viagra was originally created for the treatment of cardiovascular diseases. Its developers assumed that sildenafil citrate (the active substance of the drug) will increase blood flow to the heart muscle and reduce blood pressure. But such an effect was never achieved. Instead, in men who took this drug at the testing stage, the blood flow in the penis was restored, which led to the appearance of a quality erection.

Viagra was the first drug taken for a full recovery of an erection that occurs solely with sexual arousal.

Usually, those taking Viagra wonder how safe it is to take Viagra and if it has side effects. During clinical trials of the drug, it was found that 2.5% of men reported some adverse symptoms after taking the drug. Sometimes taking Viagra can provoke a mild headache, redness of the face, the appearance of heartburn with Viagra, nasal congestion, and color rendition. In this case, Viagra does not affect the visual acuity in any way – it has already been proved.

Viagra is safe to take with almost all drugs, including those used to treat diabetes, dilute the blood, as well as antacids, aspirin, and others. But it is not worth combining it with nitrate drugs used to treat heart diseases – there is a chance to get a sharp drop in blood pressure. Do not experiment with health and don’t take Viagra in combination with other drugs designed to enhance the erection.

How Does Viagra Cause Heartburn?

Indigestion, dyspepsia, and heartburn can be side effects of Viagra. And if you’re already suffering from heartburn, taking Viagra can only make it worse. Why do I get heartburn with Viagra? Viagra leads to the fact that smooth muscles in the penis relax, allowing the blood flow to cause an erection. But the drug also relaxes other smooth muscles in the body, including the sphincter that closes your stomach from the esophagus. This leads to the fact that the stomach acid goes up the wrong way.

How to avoid heartburn with Viagra? To prevent heartburn, you can take an antacid before or with Viagra. Also, some say that drinking a lot of water reduces or eliminates the heartburn. When using the drug, it’s also recommended to limit the intake of alcohol as it relaxes the esophageal sphincter, making the problem worse. You can also try having sex standing up.

Viagra Price Formation, Patents and New Cheap Types

Until recently, high retail prices were among common reasons why men discontinued Viagra treatment. In 2015, a single pill of branded Viagra cost $60 in the United States, but suffering from impotence, men readily paid the price to enjoy sex again. Today the price range is incredible, and pills which are essentially identical can be bought for something between $40 and 90 cents. While reasons for such price diversity remains unclear to many, potential consumers are often puzzled by choosing from a wide selection of brand and generic ED medications. Here are the main reasons why brand-name Viagra is so ridiculously expensive and its imported replicas hardly cost anything.

Viagra, the one and only

The invention of sildenafil, a potent chemical compound with erection-improving properties, was a sensation in the pharmaceutical market. Being the first-ever oral medication for ED treatment, the new drug marketed as Viagra caused a vigorous response, since erectile dysfunction has been a widespread and desperate condition with no efficient treatment available. Although sildenafil was discovered back in 1989, it gained approval for sale in the US and Europe first in 1998. Pfizer has spent more than 10 years for drug development and clinical studies that would convince the world that Viagra is safe and efficient. When the drug was finally approved, Pfizer, as the patent holder, had the exclusive right to market Viagra, one-of-a-kind pill that instantly removed the signs of erectile dysfunction. However, large R&D investments was not the only and not the main reason why the blue pill became so expensive.

Pricing in the pharmaceutical industry

Although retail prices for pharmaceutical products are developed differently depending on particular state policies, there are two main principles. Market-based pricing mechanism is based on supply and demand for the product. High product attractiveness, quality and exclusivity naturally result in higher prices. The second is related to government intervention in drug pricing, which is carried out quite differently in the world’s countries. This gives some understanding why Viagra prices in the US are the highest in the world. The US government, unlike most other countries, does not control prescription drug prices, to attract more capital into innovative drug development. However, as a result many people are not being able to afford the necessary drugs when the prices get to high. Having the exclusive right to market Viagra, which is highly demanded and has little competition, Pfizer used the opportunity to make a fortune on the famous blue pill.

Viagra price drop expected in 2020

While Viagra remained the only ED pill for a certain time, soon the world saw its first competitors, Cialis (tadalafil, approved in 2003) and Levitra (vardenafil, approved in 2003). The properties of these drugs are almost identical, and the later two possess particular advantages over Viagra. Obviously, Pfizer had to maintain a competitive price, even though it remained too high for many consumers. Patent expiration, however, will finally bring a real price drop that everyone have been waiting for. The company received an exclusive right to market Viagra for 20 years, and the present patent will expire in April 2020. This will open the way for numerous Viagra generics imported from India and China, where these drugs hardly cost anything. Pfizer has already prepared for the inflow of cheap Viagra analogs and announced the launch of its own generic Viagra, which will be much cheaper than the original.

Cheap Viagra from India and China

An inquisitive buyer will wonder why there are so many generic Viagra offers on web, pills being mainly produced in India and China. In comparison with brand-name Viagra, generic sildenafil drugs costs mere pennies, some online pharmacies offering pills for 50 cents only. Although online pharmacies assure high quality and efficiency, their products cause both interest and concern. Customers have a hard time believing that products with such enormous difference in price can give the same result. Aren’t Pfizer’s patents valid in India, anyway?

According to Indian law, patents cover only the manufacturing process and not the product itself. Simply put, Indian companies can freely produce any pharmaceutical drugs. This legal practice has been a headache for many pharmaceutical giants, who eventually had to give up trying to enforce their patents in the country. This circumstance has not only advantages in high market competition and low drug prices, but also weaknesses associated with a large volume of low-quality products. However, many Indian products still show decent quality and efficiency when compared to the original. Coming to a conclusion, when buying generic Viagra from abroad, one should consider the risks and choose proven drugstores with reliable suppliers.

Conclusion

In the nearest future, a significant price drop should be expected for Pfizer Viagra, which position would be threatened by an inflow of cheap Viagra copies from abundant pharmaceutical markets of India and China. Generic drugs do not necessarily possess inferior quality, even if they are much cheaper than the original. High prices for branded drugs are often dictated not by their high quality, but by their exclusive position on the market, though this situation cannot last forever. While nowadays it is easy to order cheap generic Viagra from other countries, it should be done with caution. Viagra is one of the most frequently counterfeited drugs, which fills the market with placebo pills and potentially harmful products. Always buy generic Viagra in reliable online pharmacies to save money and ensure getting a quality product.


Disclaimer: The information on this website in intended for reference purposes only; it should not be used for self-diagnosis and self-therapy, which can lead to undesirable consequences. In writing this article, the author sought to use the most accurate information available in the public domain. This does not mean, however, that readers can fully rely on it when dealing with health issues. Only a certified health worker should diagnose and pick optimal treatment for the patient, prescribe drugs and approve the use of particular pharmaceutical products.

6 Tips To Check Generic Medications For Quality After Delivery


The abundance of generics on today’s pharma market

Did you know that every medication has a generic name? It is almost always the name of the med’s active component that makes the medication work. To make possible a research and off-set costs of developing new medications, the FDA allows a developer a new med to be strictly the only one to throw on the market for a specified period of time. When the said period is over, other manufacturers can launch a drug made with the same active ingredient and start promoting it. These are usually referred to as generics.

Generic Medications

According to the law and regulations issued by the controlling organs, a generic medication must feature the following:

  • Contain the same active ingredient(s) as the branded medication.
  • Be equal in strength, dosage form, and the ways of administering.
  • Work the same way in the human organism.
  • Meet the same standards and follow the same guidelines for identity, strength, purity, and quality.

What would be the ways to check your generic Med for Quality Upon Delivery:

If you purchased a medication through online pharmacy, or obtained a generic through a regular shop, either prescribed or prescription-free, you might want to consider the following ways to make sure your generic medication is efficient and is in compliance with the existing standards. Remember, your safety is your priority. It will take a little time to make sure the generic is of a proper nature, but it can take significantly reduce costs often associated with misguided meds.

  1. Make sure your medication has a “narrow therapeutic index”

This means the dosage needed for the medication to work inside your systems is not much lower than the dosage that can be a possible cause of adverse effects.

  1. Make a habit to keep the track of your medical progress

If you are happen to be, for example, on blood pressure medications, invest a little money and buy a home blood pressure monitor, take the consequent readings two times a day for a while, and take them down. The same applies if you happen to have diabetes, etc. Keep the record of results of lab tests. Bring all of these records to your physician if you suspect that your generic medications are not of proper efficacy.

  1. Always self-monitor how do you feel

There are generic medications for existing conditions that do not suggest any lab tests, which could have helped in tracking and making sure the medications are applied as a proper treatment for a proper condition. Such conditions include for example a wide range of psychiatric conditions, such as generalized depressive disorder, anxiety disorders, borderline disorder, etc.

In such case there might be the only way to establish how the generics work on you. It will help to break down your day, and fill in corresponding boxes on a paper, checking, if you feel, “moderately good,” “good”, etc. If how you feel does not change with time, while you are on the generic medication, it is time to question the meds efficacy.

  1. “Challenge” your generic medication

If you for some reasons suspect your generic is not what it said it is, ask your physician to put you on the branded medication with the same active component. After the brief course (from two weeks to a month), go ahead and try the generic again. This technique is known as a drug challenge. This way you can establish for sure the efficacy of the drug.

  1. Always ask the pharmacist for the name of the manufacturer

Not all generic medications work the same way–and if you keep track, you will find that you have better results with a med from a particular manufacturer as compared to the same med from another manufacturer. However, because your pharmacy can switch providers whenever it finds a better deal (and it usually does so, business as usual), you may have to shop around to find the particular med you want.

  1. Switching versions

If a once a day formula is not working for you, a medication designed to be taken two or three times per day might be a better option. Make sure to consult your physician, if that course would be applicable in the case of hesitations.

FAQ About Canadian Pharmacy: Information On Medications & Services

Canadian Pharmacy is an online store distributing drugs. It is established for the convenience of customers and provision of high-class service. In this article, we answer the frequently asked questions about online pharmacies in Canada, in general, and My Canadian Pharmacy, in particular, that come through the website and on the phone.

Pharmacy

Why choose My Canadian Pharmacy?

At My Canadian Pharmacy, there is one of the most extensive assortments of rare drugs, branded medicines and generics in the U.S. and Canada. We know everything about meds selecting only the best and high-quality solutions for you. The prices are significantly lower than in offline pharmacies. Plus, the delivery of drugs in throughout Canada and the United States is performed on the day of order. We give quality warranty and make a refund or replacement upon request.

Why are generics cheaper at My Canadian Pharmacy?

For the convenience of our buyers, we launched an online store in order to remove the mark-up from the cost of drugs for the rental of retail space which is practiced in ordinary pharmacies. Thanks to this, customers are serviced by reduced staff, and the process of ordering and organizing delivery is automated. We receive generics directly from the manufacturer, reducing their cost through bulk purchases and the absence of intermediary margins.

How to order a drug at online Canadian pharmacy?

Checkout of the necessary medicine can only be through the website with the help of a “basket”, callback or online consultant. After processing the application, an email will be sent to your specified email address notifying of the order, then a call will made within an hour to confirm the order. When making a delivery, a courier will specify the address and convenient time for your delivery by phone.

How can I pay for the purchase at Canadian e-pharmacies?

You can choose any convenient payment method:

  • Credit card;
  • Electronic check;
  • International money order;
  • Personal check.

You can cancel the purchase at any time. To do this, just send a message through the website. During the day, you can also adjust the already placed order.

Do Canadian pharmacies return money with no effect?

Such situations arise very seldom. But you will fully reimburse your costs if you do not get the expected effect from the use of the drugs (or generics, such as Viagra and its generic Suhagra) purchased from Canadian online pharmacies. They always return the money or change it for the goods that were taken before (as a rule, people take a new one, and they are not happy with the effect and say that others took it before, they were better, we change them for free).

Does customer age matter?

The sale of drugs presented in the online store is not allowed to persons under the age of 18 years.

How is customer information protected at Canadian e-drugstores?

Licensed pharmacies guarantee complete security of personal data of their customers and absolute confidentiality. All data received via the online ordering system are processed in special encryption programs that provide 100% protection.

What to do when delivery is delayed?

It is urgent to contact the online pharmacy’s consultant via the website or at the phone number indicated on the webpage. They will definitely find out the reason for the delay and promptly deliver the drug.

What should I do if I made a mistake in specifying an address during delivery?

Contact the consultants of the e-pharmacy you’ve chosen through the website or by phone and your application will be duplicated at no extra charge.

What to do in case of damage of the package or shortage of tablets?

These are extremely rare cases in the practice of online Canadian Pharmacies that are usually associated with defects in the postal service. We do not find out the causes of damage or shortage, but immediately solve the problem in favor of the client – you just need to contact the support service of the online store mylegacypharmacy.com.

How to contact support service of online pharmacies?

The support service is working 24/7. You can ask a consultant a question through a special form, which is located in the lower right corner of the page. Contact the support service is also possible through the website feedback by clicking on the button ‘Order a call’ generally located at the top of the page. In both cases, they will answer you promptly and in detail.

Where are the drugs at Canadian e-stores produced?

The medicines, their generics and devices are offered by the online store are manufactured by well-known Canadian, American, European and Indian pharmaceutical companies. Find more information here.

What kind of generics can I buy at Canadian drugstore?

Through the online store in Canada you can order and buy mainly drugs and generics intended for the treatment of erectile dysfunction in men (increase potency) and increase libido in women.

Why is the price of generics lower than the one of originals?

The developers of the original drugs spent considerable amounts of money on research, testing, advertising, which is reflected in the high cost of brands. Generics are manufactured using ready-made technology which has been developed by companies producing original products. This significantly reduces the cost of production of generics, which is reflected in the price – it is much lower than that of brands, even though the composition includes the same active components.

How do generics differ from original brands?

In terms of composition and action, generic drugs are identical to the brand name of the drug, they differ only in manufacturer and name. The components that make generics absolutely identical with the brand composition. Generics are not fake, as some believe, it is a legitimate practice related to the expiration date of the patent for the original drug. Generics often differ from the brand only in packaging design, color and shape of tablets, which is also considered the norm in the pharmaceutical industry.

Why is generic name different from the brand?

This is due only to copyright: the repetition of the brand name is a violation of the law. But after the expiration of the patent for a brand, other pharmaceutical companies have the right to produce drugs with a completely identical composition, but under a different name. Usually generic drugs are named after active substance of the drug. Thus, the generic Sildenafil is named after the active ingredient of the brand Viagra, both drugs have a completely identical composition.

Top 7 Viagra Alternatives – Synthetic and Natural Pills for ED Treatment

Content: Cialis, Levitra, Kamagra, Stendra, ZydenaAlprostadil, Papaverine, Yohimbine

While Sildenafil Citrate still considered by many a very strong drug that has no serious competition, the reality is that there are medications that could be better in some scenarios or just be straight up superior due to some additional features that Viagra lacks. Before we discuss them and focus our attention on different alternatives in the market, we must talk about the brand of Viagra and why we are cursed to compare every single drug to this history altering medication that was released in 1998.

Sildenafil Citrate was not an overnight discovery that immediately changed the landscape of the pharmaceutical market. In fact, the very brand name Viagra was not conceived until late 90s while the development was at full speed for over a decade. We found PDE inhibitors way before the talks about PDE5 inhibitors started. The discussion was mostly about the property of this group of inhibitors to affect the production rate of cGMP which is a really important microelement that supervises how much NO is released to relax smooth muscles.

Initially, we believed that all drugs from the PDE5 inhibitor class were promising pharmacological treatments for angina, chest burn, and/or arterial hypertension. While it was ultimately true, one particular adverse effect changed the direction taken by the initial developer of Sildenafil Citrate. Pfizer started exploring ways to use Sildenafil in the end of 1980s. By the beginning of 1990s, they were testing the drug clinically to approve it as a drug against arterial hypertension. During tests, scientists discovered that patients who took the drug reported huge improvements to their erectile function regardless of whether they had issues related to erection or not.

The commercial potential was obvious and the company decided to dramatically shift the direction of clinical trials. Viagra was released in 1998 after being approved by FDA and successfully passing a long series of clinical tests. The new medication proved to be very effective in over 80% of cases. This was a drug that overwhelmed the market not only by its aggressive and highly impactful marketing campaign, but also by a really positive word of mouth. Men were sold on advertisements and told each other that the drug actually works and helps tremendously.

In the following decade, we saw an influx of other brands. Simultaneously, a bunch of new generics started to appear in national markets and level the playing field internationally. The age of alternatives had begun. However, the initial success of Viagra was so massive that people are convinced that there are no better options. Well, we want to make it clear that truly effective alternative medications do exist and you can easily purchase them for a low price in online shops and even your local pharmacies.

Cialis/Tadalafil

The first true contender for the place of the best erectile dysfunction drug appeared in November 2003. While the direct competitor of Viagra appeared a couple of months earlier, Cialis received a much better warmer welcoming and became hugely successful in a glance of an eye. Chunks of market were torn by a marketing campaign from Lilly ICOS. Cialis was an undeniable success.

There were several reasons why the new medication took off so well and managed to push away the juggernaut of Viagra. We can summarize some of pivotal reasons in three simple lines:

  • Cialis kept being active for up to 40 hours after the initial intake;
  • Cialis could be used as a recreational once-per-day drug;
  • Tadalafil became a very effective medication to treat early stages of BPH.

This made the newcomer a more attractive option for many patients who were looking for a drug that would actually help to treat ED in a systemic manner instead of using a blue pill an hour before a planned sexual intercourse. When it was announced that the medication is also a good remedy for BPH, men started to switch from Viagra to Cialis rapidly. The change of the mood in the market was quite palpable.

If you are looking for a treatment that would help you to stop planning all your romantic endeavors and give you a good way to counteract and slowdown some of symptoms characteristic for benign prostate hyperplasia. The only downside that we can think of is that it is way more expensive and should be purchased in bulks if a patient wants to sustain a systemic treatment plan.

Levitra/Vardenafil

In August 2003, the market quietly welcomed the arrival of Levitra. The initial marketing campaign was small and not as loud as some would have expected. This was a direct competitor to Viagra. Vardenafil has nearly the same pharmacodynamics and shares a lot of similarities with Sildenafil including the half-life period. While Cialis has a 17.5 hour half-life period allowing it to stay in the body for up to 36-40 hours, both Vardenafil and Sildenafil have a mere 4 hour half-life period. Different reports have slightly differing periods, but both drugs work roughly similarly in terms of action time and persistence of the effect.

Levitra did not gain a lot of traction initially as many perceived it as a clone of Viagra. Not many people actually understood why they should use this new medication if the old one works just well. However, the marketing of Levitra was slow but informative and soon people started to learn what was the real catch.

Levitra is a drug that has two distinct effects on the male body:

  1. Helping to achieve erection through a mechanism very similar to that of Viagra;
  2. Extending the intravaginal latency to make men last longer in bed.

Vardenafil was a life-saver for men who experienced complex sexual dysfunctions. Erectile dysfunction is not the only problem that plague men. Modern sexual standards demand men to maintain erection for longer periods of time and even a small increase to intravaginal latency was a welcomed addition to the arsenal of a struggling man. Soon enough, Viagra had to give up some more space on the market to a drug that was actually superior in every conceivable way and lost only in marketing. However, both these drugs were soon challenged by another interesting medication that became very popular amongst men in North America.

Stendra/Avanafil

Another huge competitor arrived to the NA market in April of 2012. Another PDE5 inhibitor Avanafil was approved by the FDA and entered the market under two trademarks Stendra and Spedra. The success rate, effectiveness, and dosages were very similar to both Levitra and Viagra, but this new drug had a very distinct advantage to quickly start making more space for itself in market.

Avanafil has the shortest adsorption rate amongst all approved PDE5 inhibitors. This significantly shortens the onset of action. While Viagra and Levitra may take up to 1-2 hours to start working, Stendra “kicks in” within minutes after the intake. When used on empty stomach or after a very light meal, the drug start working after 30 minutes. Amongst test subjects about 60% were capable of achieving strong erection within 15 minutes with some reporting signs of erection even earlier.

The half-life period is way shorter compared to other similar medications, but the onset of action being so short is a definitive benefit. If you are a person that never plans ahead and want to be ready for action at any given moment of time, there is no better choice than Stendra and its analogs. This is a great quickly working medication with the same effect as your trusty Viagra. Another important advantage is the price tag which showcases comparatively low numbers especially compared to other similar drugs in the market.

Zydena/Udenafil

Another next generation PDE5 inhibitor that is waiting for the approval from the FDA alongside Helleva from Brazil. One of the most effective and quickly working PDE5 inhibitors to date, Zydene is a drug that can be purchased online in some pharmacies for personal usage. This is a medication that has several advantages compared to Viagra. For example, Zydene has a short onset of action reaching the maximum concentration in plasma in less than 90 minutes meaning that you can expect the drug to start working within 1.5 hours after the intake. When taken on empty stomach, the drug starts working within 30-60 minutes.

The medication is very effective and works similarly to Viagra. Udenafil relaxes smooth muscles that control arteries and allows the blood fill cavernous penile tissues allowing for strong erection. Udenafil would have been very similar to Levitra/Viagra if not for an extended half-life period of 12 hours which allows the medication to stay active for up to 26 hours in your body.

This means that the drug is not only highly effective. It starts working faster than Viagra on average and persists in the body for longer periods of time. This is a perfect choice for people who want to have a reliable and backed by experts medication that would be superior to Viagra in every way possible including the price. We expect the drug to be approved in the beginning of 2018.

Alprostadil/Prostaglandin

One of the most interesting drugs against erectile dysfunction that was discovered over half a century ago in 1957. Initially used to treat toddlers with congenital heart defects. However, scientists later noticed that a direct injection of a small amount of prostaglandin in a flaccid penis helps to achieve and maintain erection for a long time. After a series of clinical tests, the drug was approved by the FDA for treating erectile dysfunction and entered the market in an injectable form. Later, a urethral suppository option was also introduced the market.

For a long time, men could purchase only an injectable form or opt for special mixes available as generic drugs in the open market. You can purchase prostaglandin in online pharmacies and store it in bulks in a refrigerator to use when needed in small quantities. However, this is a very effective yet inconvenient treatment method that drove away many people especially since much more convenient and easy-to-use methods started arriving to the market. Namely, PDE5 inhibitors in pills that immediately made prostaglandin an outdated solution.

Just a couple of years ago, the drug was made into a form of a cream that could be applied to penis and skin around it to improve the blood flow and help in achieving erection. The effectiveness of this administration method is not as great as an injection and the medication fails in a small percentage of cases. However, this is a very convenient method of using a time-tested medication that has been around for over 50 years.

Papaverine

One of the oldest drugs in the market and has been around for literally centuries and introduced to western medicine in the middle of 19th century. This compound is extracted from opium poppy seeds and has been used as a drug against spasms and arterial hypertension as well as an herbal solution against erectile dysfunction with a 70% success rate. 7 out of 10 patients report minor improvements to their conditions. There are various ways to use it.

Some specialists suggest using it as a systemic solution and prescribe one or two tablets per day depending on dosage and pill strength. Some specialists suggest combining this drug with other medications but not PDE5 inhibitors. The thing is Papaveine is a vasodilator and will lower the blood pressure when injected in penile tissues. When combined with PDE5 inhibitors like Sildenafil or Vardenafil, the drug may cause a life-threateningly low level of blood pressure. In order to avoid such dangerous situations, consider using Papaverine as a standalone medication and consult with your doctor.

Yohimbine/Ginger root/Lotus root

There are various herbal alternatives to Viagra and Levitra. However, none of them work as efficiently or can be used as a really good first-level treatment. If you need results, you will never try herbal drugs before using time-tested solutions that have been around for decades. We do know that Viagra and Levitra help. However, there is insufficient data on Yohimbine or other plants that supposedly improve the erectile function. Despite claims of healers and herbalists, these extracts are far from being effective and will more often than not be absolutely useless.

An important thing to note is that many herbal drugs are usually approved by the FDA as dietary supplements and not actual medicines. At the same time, many Ayurveda drugs and herbal mixes can be toxic or otherwise dangerous to human body. There are other downsides to using untested unreliable medications.


Conclusion

There are myriads of medications that could be considered good effective alternatives to Viagra. Sildenafil was a gigantic sensation nearly 2 decades ago but it is not a miracle anymore and many other drugs became even more relevant. New up and coming drugs will inevitably push away the brand of Viagra. With the arrival of generics, you have such a wide choice of medications against ED that overpaying for a loud brand name is not smart. Choose your drugs wisely and save instead of wasting.

Cialis Coupons 5-20% at My Legacy Pharmacy

How much does Cialis cost?

Cialis Coupons

The price of Cialis will very much depend on two key factors: where you buy your tadalafil pills and what type of pills you get. It should be noted that while paying undue extra for the pills you can get cheaper off another retailer is a folly, while paying too little is plain dangerous since no good quality drug could possibly go below $0.50 per pill. The rule of thumb here is to know the price range that marks safe shopping investment limits for both generic and brand types of Cialis.

You can bounce off these ranges for the brand medication: $29.5 (per pill of Cialis 5 mg, blisters of 30 pills) and $31.66 (per pill of Cialis 10 or Cialis 20 mg, blisters of 30 pills) – mean prices from an average pharmacy chain; and $1.48 (per-item price on a bulk order of Cialis 5 mg, 80 pills blister) through $2.72 (per-item price on 30 pills blister offer on Cialis 20 mg).

Money-saving maths with Cialis coupons

Cialis coupons is the talk of the town – little it is surprising, for this artefact is able to bring the price of Cialis as low as 10% down. But it is as evasive as it is popular. Try googling it, and you are certain to get nothing but a handful of empty promises by rogue online pharmacies that are here today and gone tomorrow, with no reputation under their belt. Do not get discouraged though – if you know where to look, you will find an offer that will land you with a good quality pill for a fair price.

GET YOUR COUPON CODE:


Coupons for Cialis in your mail!

Becoming a registered subscriber to My Canadian Pharmacy is pregnant with possibilities. First and foremost, you get the front-row access to the coveted coupons for Cialis (and many other high quality drugs!). Apart from enrolling in loyalty program that pays off with lower prices for each and every item from suggested (hand-picked and safety-tested!) retailers, special offers day in, day out, free delivery coupons, and so much more, you will enjoy exclusive pass to the best online deals on Cialis, Viagra and other men’s health products. The best part of it is that you will hardly have to do anything other than opening your inbox to start saving money on high quality signature medications.

Cialis free trial at My Canadian Pharmacy

Apart from all of the above, regular customers of our pharmacy and first-timers alike will enjoy 4 (four) free trial pills of Cialis or Viagra, subject to shopper’s choice, with every order. This offer stands for every customer and any order amount. Our tip is to choose free trial pills of Cialis when ordering Viagra, and the other way around. In this way, you will have the double win of both unique drugs that can be alternated between for a truly customized use.

Over 70 percent of Floridians have two or more doctors

A recent research has found out that a vast number of Florida residents use services of two and more healthcare providers simultaneously. Most often Floridians combine services of physicians and narrow specialists like dentists, gynecologists and sexual health doctors, physiotherapists and other specialists.

Key benefits of such approach is getting comprehensive healthcare information, listening to multiple opinions of various specialists and timely treatment of all conditions and diseases.

Over 70 percent of Floridians have two or more doctors

However, getting prescriptions from two and more doctors and take several medications at once may not be completely safe. Usually drug interactions are listed in the instructions that you get after purchasing the drug in a pharmacy or online drugstore. Nevertheless, in some cases in may not be completely clear for people with no special medical education: sometimes we fail to relate active substances to brand names and vice versa. It may lead to uncontrolled medication intake and dangerous combinations.

How to avoid unhealthy or dangerous drug combinations?

After you get meds prescribed and before ordering them at any online pharmacy it is better to consult specialists online and specify all medications, supplements and herbs you are take regularly or had been taking up to 2 weeks prior to consultation. This is very important as when ignored drug combinations may decrease the efficacy of each, cause allergic reactions and may lead to even more serious consequences. We recommend that you stayed well-informed and very attentive to your health!

At our legacy pharmacy we have a unique program implemented. It analyzes all your existing prescriptions and contact your doctors to make sure the combination of drugs is safe and effective.

For example, if you are ordering erectile dysfunction medications, it is especially important to pay attention to other group of drugs, such as: nitrates or “poppers” prescribed for people with cardiovascular diseases, drugs intended to treat chronic diseases (kidney, liver and other diseases), as well as anything you can remember. Antibiotics should not be combined with a certain number of other drugs, with alcohol and so on.

It’s a great idea to make use of various healthcare services from different providers, especially, when such consultations are covered by your insurance. However, try to be cautious and rational: always carefully read instructions before using any medications and shop at our pharmacy to be sure you avoid dangerous drug interactions, get high-quality meds that have undergone several clinical studies in different countries.

We deliver exceptional care of our customers and do our best to make your online pharmacy shopping fast, safe and effective! Visit My Canadian Legacy Pharmacy website for more information on: electronic algorithm for prescription analysis, drug variety in stock, delivery terms, special offers and discounts, information about treatment results, drug interactions and possible side effects.